Multiple emulsions are complex systems, termed "emulsions of emulsions", i.e. the droplets of the dispersed phase contain even smaller dispersed droplets themselves. Each dispersed globule in the double emulsion forms a vesicular structure with single or multiple aqueous compartments separated from the aqueous phase by a layer of oil phase compartments. The multiple emulsions are considered to be promising drug delivery systems by virtue of their thermodynamic stability, macroscopic homogeneity, ease of preparation and small droplet size . Multiple emulsions of w/o/w and o/w/o types (more correctly, double emulsions) are becoming popular since an additional reservoir is presented to the drug for partitioning which can effectively retard it release rate. This parenteral multiple emulsion have many advantages such as which include ease of application, localized delivery for a specific action. Prolonged delivery period, decreasing body drug dosage with concurrent reduction in the possible undesirable side effect common to most form of systemic delivery and improved patient compliance and comfort. By the incorporation of combined chemotherapeutic agents in the parenteral multiple emulsion enables the simultaneous attack of different biological targets, thus enhancing the effectiveness of treatment and they are less likely than older tumors to develop drug resistance.
Loading....